Author Archives: CS

Root Cause Analysis and Tools Used for RCA- Pharmaceuticals

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Root cause analysis is a methodology to find the primary cause of problem, by tracking back the actions which lead to the nonconformance(problem) and helps to solve the problem.

Root cause analysis is used to identify the problem. What happened? why it happened? and then to determine, what improvements or changes are required to overcome the problem. How it can be prevented in the future.

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Light intensity for Pharmaceutical Area

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Lighting at work is very important to the health and safety of everyone using the workplace. Poor lighting can affect the health of the people working in any industry causing headaches, eye strain, and migraine. Poor lighting can harm the business in the form of errors in work, absenteeism, and reduced staff efficiency and productivity.

Excessive lighting can cause glare. Glare is of two types disability glare and discomfort glare. Disability glare is the one when there is direct interference of light with vision resulting in impairment. In discomfort glare vision is not directly impaired, but it may cause discomfort, annoyance, irritability, or distraction the condition is called discomfort glare.

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Climatic Zone and Stability Study Conditions as per ICH Guidelines

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The climatic condition changes as we move across the globe, which means that the climatic condition is different in a different part of the world. Now since the stability of pharmaceutical product is influenced by climatic conditions, the stability study of the pharmaceutical product needs to be studied keeping in mind the climatic conditions of the country. As per ICH guidelines for stability studies, the climate of the world is divided into four different zones (Zone I, II, III, IV.). Zone IV is further divided into two, zone IV A and zone IV B.

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System Suitability Test Requirements in Chromatography

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The operation parameters of the whole chromatographic system can be checked with properly selected SST mixtures. System suitability testing limits are the acceptance criteria that must be met prior to the use of sample analysis.

The system suitability testing limit should conform to criteria provided in guidelines by CDER and other pharmacopeial references like USP and ICH. Some of the parameters which can be checked as SST requirements are: 

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IGIB uses mass spectrometer for coronavirus detection — Science Chronicle

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IGIB researchers have been able to detect novel coronavirus using mass spectrometer. The detection is based on the presence of two unique peptides of the virus. Sensitivity is 95% and specificity is 100% and takes less than 30 minutes from sample preparation to testing. Using mass spectrometer, researchers at the Delhi-based Institute of Genomics and […]

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IGIB uses mass spectrometer for coronavirus detection — Science Chronicle

Friability Testing – Friability of uncoated tablets

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Friability (the condition of being Friable) testing is a methodology, used to see the physical strength of compressed and uncoated tablets upon exposure to mechanical shock and attrition. In simple words, what quantity of mechanical stress tablets will stand up to throughout their production, distribution, and handling process.

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Early detection of cancer using a blood test

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Blood test is one of the simplest, yet most informative weapons in your doctor’s arsenal. A tiny needle prick and a few millilitres of blood can help doctors 1) evaluate how your body’s vital organs like heart, liver, kidneys and thyroid are functioning, 2) diagnose diseases such as diabetes, cancer, heart disease and communicable diseases […]

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Early detection of cancer using a blood test — cuppascience

A case of coronavirus reinfection in Hong Kong confirmed by genome sequencing

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Using genome sequencing, researchers at the University of Hong Kong have found a rare instance of reinfection with novel coronavirus for the second time, four-and-a-half months after the first infection. The first viral genome belongs to GISAID clade V, while the second genome belongs to GISAID clade G. Using genome sequencing, researchers at the University […]

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A case of coronavirus reinfection in Hong Kong confirmed by genome sequencing

Children have more coronavirus during early infection phase than hospitalised adults

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Researchers found that children infected with novel coronavirus have viral load comparable with adults admitted to ICUs. But during the early infection phase, children can have significantly higher viral load than COVID-19 adults in ICUs. Viral load decreases over time in children. Age of children did not have any impact on viral load. Researchers Massachusetts […

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Children have more coronavirus during early infection phase than hospitalised adults