Intranasal vaccination of a coronavirus candidate vaccine prevents infection

A new vaccine candidate construct using chimpanzee adenovirus carrying the full length of novel coronavirus spike protein is able to achieve sterilizing immunity and prevent both upper and lower respiratory tract infection in mice when administered intranasally but not when given via the intramuscular route. A new vaccine candidate construct using chimpanzee adenovirus carrying […] ToContinue reading “Intranasal vaccination of a coronavirus candidate vaccine prevents infection”

COVID-19: Saliva is a viable alternative to nasopharyngeal specimen in asymptomatic persons

In a mass-screening study of 1,924 asymptomatic persons, self-collected saliva samples had sensitivity (92%) and specificity (over 99.9%) comparable to nasopharyngeal specimens — sensitivity 86% and specificity over 99.9%. The true concordance probability between the nasopharyngeal and saliva tests was estimated at 0.998. In a mass-screening study of 1,924 asymptomatic persons using nasopharyngeal and self-collectedContinue reading “COVID-19: Saliva is a viable alternative to nasopharyngeal specimen in asymptomatic persons”

FDA approves rapid, inexpensive saliva test for coronavirus

A rapid, inexpensive saliva test developed by Yale School of Public Health in partnership with NBA has high sensitivity. The testing protocol has been made available through “open source”. The SalivaDirect test does not use any preservative at time of collection, uses commonly available reagents, and does not need equipment for nucleic acid extraction. InContinue reading “FDA approves rapid, inexpensive saliva test for coronavirus”

Buffers and Guidelines on the use of buffers in HPLC Methods

A buffer solution is a solution that resists changes to a solution’s pH when small quantities of acid or alkali are added. pH change can separate two closely eluting peaks and may merge two separate peaks, Hence the use of buffer plays an important role in HPLC separation. The most commonly used buffers in LC are citrate, acetate and phosphate buffer.Continue reading “Buffers and Guidelines on the use of buffers in HPLC Methods”

Total Quality Management in Pharmaceutical Industry

Introduction: Total Quality Management is a systematic approach for the continual improvement of all Organization processes, through the participation of all the staff, leading to prime quality product and services to achieve customer satisfaction It is supported by the philosophy: “Do the right things, right first time, every time”. Principles of Total Quality Management: TheContinue reading “Total Quality Management in Pharmaceutical Industry”

Quality Management System in Pharmaceuticals

A Quality Management System (QMS) is defined as a system that documents processes, procedures, and responsibilities for achieving quality policies and objectives. QMS is the core of the quality and compliance process for any organization. It helps in the reduction of audit time and findings, it also helps in product recalls. A QMS helps coordinateContinue reading “Quality Management System in Pharmaceuticals”

Introduce Yourself (Example Post)

This is an example post, originally published as part of Blogging University. Enroll in one of our ten programs, and start your blog right. You’re going to publish a post today. Don’t worry about how your blog looks. Don’t worry if you haven’t given it a name yet, or you’re feeling overwhelmed. Just click theContinue reading “Introduce Yourself (Example Post)”