My Blogs

  • 5 Why tools for Root cause analysis in pharmaceuticals

    September 27, 2023 by

    Originating in the manufacturing industry, the “5 Whys” analysis technique has found effective adaptation and application in various fields, including pharmaceuticals. It involves asking “why” multiple times (typically five) to dig deeper into the root causes of a problem. In the context of pharmaceuticals, the 5Whys tool can help identify the underlying causes of quality… Read more

  • Evaporative Light Scattering Detector(ELSD)

    September 25, 2023 by

    ELSD stands for Evaporative Light Scattering Detector. It serves as a type of analytical instrument in chromatography for detecting and quantifying non-volatile compounds lacking a natural chromophore or fluorophore. It proves especially valuable when analyzing compounds that UV, fluorescence, or conductivity detectors, commonly used in chromatography, cannot detect. How ELSD Works: Applications of ELSD: In… Read more

  • Refractive Index Detector (RID)

    September 25, 2023 by

    A Refractive Index Detector (RID), also known as a Refractometer or Refractive Index Detector, is a detection device commonly used in High-Performance Liquid Chromatography (HPLC) and other liquid chromatography techniques. RIDs operate based on the principle of measuring changes in the refractive index of a sample as it elutes from the chromatographic column. Here are… Read more

  • Fluorescence Detectors(FLD)

    September 24, 2023 by

    Fluorescence Detector (FLD) is a specialized analytical instrument used to detect and quantify fluorescent compounds in various samples. It operates on the principle of fluorescence, a process where molecules absorb light at one wavelength and then re-emit it at a longer wavelength. Here are the applications and uses of fluorescence detectors: Applications of Fluorescence Detectors:… Read more

  • Diode Array Detector

    September 24, 2023 by

    Diode Array Detector (DAD), also known as a UV-Visible Detector, is a type of detector commonly used in analytical chemistry techniques like High-Performance Liquid Chromatography (HPLC) and other forms of liquid chromatography. It differs from a single-wavelength UV detector in that it can simultaneously measure absorbance at multiple wavelengths across the UV-Visible spectrum. Here are… Read more

  • UV VIS Detector and it’s application

    September 23, 2023 by

    A UV-Vis (Ultraviolet-Visible) detector is a common analytical instrument used in chemistry and biochemistry to measure the absorbance of ultraviolet and visible light by a sample. Principle and Component of UV-Vis Here are some key points about UV-Vis detectors and their applications: Application of UV-Vis New Watches Collection Limitation: Limitations: UV-Vis spectroscopy is limited to… Read more

  • Different Types of HPLC Detectors

    September 22, 2023 by

    High-performance liquid chromatography (HPLC) detectors are essential components of HPLC systems that help identify and quantify analytes in a sample as they elute from the chromatographic column. There are various types of HPLC detectors, each with its own strengths and limitations. Here are some common types of HPLC detectors: The choice of detector in HPLC… Read more

  • Hausner’s Ratio

    September 19, 2023 by

    Hausner’s ratio, also known as the Carr’s compressibility index, is a measure used in the pharmaceutical industry to assess the flowability and compressibility of powders and granular materials. It is a simple way to predict how well a powder will flow and how easily it can be compressed into tablets or other solid dosage forms.… Read more

  • Angle of repose

    September 13, 2023 by

    The angle of repose is an important concept in pharmaceuticals and various other industries. Importance of Angle of Repose

  • ICH Guidelines

    September 12, 2023 by

    The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) provides guidelines to ensure the quality, safety, and efficacy of pharmaceutical products. These guidelines cover various aspects of drug development and regulation, including: Q1: Stability Testing of New Drug Substances and ProductsQ2: Validation of Analytical ProceduresQ3: Impurities in New Drug SubstancesQ4:… Read more

  • Dissolution Testing

    September 9, 2023 by

    Dissolution testing is a critical process in pharmaceutical development. Dissolution testing is a critical quality control and research technique used in the pharmaceutical industry to assess the rate and extent of drug release from a solid dosage form (e.g., tablets, capsules) into a dissolution medium that simulates physiological conditions. The results of dissolution tests are… Read more

  • Data integrity Principle: ALCOA to ALCOA Plus

    May 12, 2021 by

    ALCOA is a commonly used acronym for “attributable, legible, contemporaneous, original and accurate”. Data needs to be complete, consistent, enduring and available along with all other attributes mentioned in definition. ALCOA Plus includes all the attributes of ALCOA, plus an additional attributes “complete, consistent, enduring and available” as completeness, consistency, durability and availability is important… Read more

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